The differing physiology of nitrogen and tracer gas multiple-breath washout techniques
نویسندگان
چکیده
منابع مشابه
A mathematical evaluation of the multiple breath nitrogen washout (MBNW) technique and the multiple inert gas elimination technique (MIGET).
We consider two and 50 compartment lung models for use with two techniques used to investigate the efficiency of the lungs: the Multiple Breath Nitrogen Washout (MBNW) technique used for investigating the ventilation-volume distribution; and the Multiple Inert Gas Elimination Technique (MIGET) used for investigating the ventilation-perfusion distribution. In each of these techniques pulmonary r...
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BACKGROUND Accurate estimates of multiple breath washout (MBW) outcomes require correct operation of the device, appropriate distraction of the subject to ensure they breathe in a manner representative of their relaxed tidal breathing pattern, and appropriate interpretation of the acquired data. Based on available recommendations for an acceptable MBW test, we aimed to develop a protocol to sys...
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BACKGROUND The lung clearance index (LCI), measured by multiple breath washout (MBW), reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis (CF) lung disease. Current evidence is based on a customized mass spectrometry system that uses sulfur hexafluoride (SF6) as a tracer gas, which is not widely available. Nitrogen (N2) washout may be better suited for c...
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Nitrogen excreted from body tissues impacts the calculation of multiple breath nitrogen washout (MBWN2) outcomes. The aim of this study was to determine the effect of tissue N2 on MBWN2 outcomes in both healthy subjects and patients with CF and to assess whether it is possible to correct for tissue N2. The contribution of tissue N2 to MBWN2 outcomes was estimated by comparing MBWN2-derived func...
متن کاملMultiple-breath nitrogen washout techniques: including measurements with patients on ventilators.
Definition ....................................................................... Methods for determining FRC ................................... Choice of method FRC measured by plethysmography (FRCpleth) ......... FRC measured by helium dilution (FRCHe) ............. FRC measured by nitrogen washout (FRCN2) ........... Standards for lung volume measurement by gas dilution/washout techniques ...
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ژورنال
عنوان ژورنال: ERJ Open Research
سال: 2021
ISSN: 2312-0541
DOI: 10.1183/23120541.00858-2020